[1] the modern theory of aging senior Chinese medicine health care ' _

As early as in ancient Greece, Hippocrates on aging problem is studied. Since the nineteenth century, now there are hundreds of doctrine, but aging mystery has not yet been completely solved. In recent years, with the development of science and technology, in particular, immunology, molecular biology, protein chemistry of rapid development and modernization of test instruments to enable discussion of the doctrine of anti-aging for entering a new phase, with many theories, here are just examples of the main 11. 1, central nervous system dysfunction doctrine of human brain approximately 140 billion neurons, from birth until 18 years old or so, change the number of brain cells, but starting from adult, brain cells die because of the degradation and gradually. To 60 or so would lose half. At the same time, the motor nerve conduction velocity and sensory nerve conduction velocity also increases with age, and began to affect intellectual and intimate environment. All physiological systems are displayed and age-related changes, but the central nervous system changes in the aging behavior and other several features change aspects play a major role. Now many of these features by hypothalamic-pituitary systems. 2, autoimmune doctrine autoimmune doctrine from cells, organs and individual levels explain aging causes. Extensive information confirms that the following two points: �� senile normal immune potential reduction; �� autoimmune activity increases. Wolfram de et al. 1962 according to aging mutate cells stimulate the immune response, but also the substance of the body's cells damage, autoimmunity, and thus explain the theory of aging. Under normal circumstances, the body's immune system does and its organizational components of the immune reaction occurs, but the body in many harmful factors (such as a virus infection, drugs, radiation, etc.), the immune system of certain own organization as Antigen immune reaction that occurs. This phenomenon on the organism's cells, tissues, and organs to produce many harmful effects, so that the body produces autoimmune disease, in order to speed up the aging organism. 3, the poisoning of the doctrine itself that aging is due to various metabolites accumulate in the body, leading to cell death by poisoning. Human intestinal sojourn in a large number of bacteria, especially e. coli bacteria more, these bacteria in the gut by decomposition and fermentation, can produce large amounts of toxins, these toxins for differentiation in the most obvious, way more complex cell and organ damage most, finally died of poisoning by itself. 4, radical theory the theory that life activities will have some free radicals, and in certain components of reaction, causing harm to the body, causing human aging. Free radicals are outer orbit ju have unpaired electrons in the molecule, they generally are very lively, there is short, it participates in normal biochemical process, only when the free radical reaction exception or runaway will cause tissue damage or body aging. The main hazards are as follows: �� oxidation body large amounts of unsaturated fatty acid, fatty degeneration, Lpo, and further decomposition produces formaldehyde cross-linking the aldehyde to protein, fat and nucleic acids; �� nucleic acid denaturation caused by and affect their ability to convey information, as well as the characteristics of transcription, replication, resulting in reduced ability of protein synthesis, and produce synthetic errors; �� protein denaturation caused as a result some of the specific protein, thus causing immune response; �� induced extracellular soluble constituents of degradation, such as will enable the synovial fluid of the variegates oxidative degradation occurs, resulting in the loss of synovial fluid, smooth and light effects on a significant damage to the joints. 5. biological clock theory in the hypothalamus in the presence of "institutional" biological clock-like control, control of cell division of speed and frequency. Such as the United States scholar hayflick discovered, a middle-aged man about 50 ~ 60 trillion cells, these cells from embryonic start splitting 46 ~ 50 times, you are no longer split, and then died, according to the number of cell divisions, human life should be 120 years, it just goes to show, aging in the organism like a "set clock" that is, the aging process is based on an established procedure, gradually pushing. All living things go through such a similar life processes, just different species and each have their specific biological clock. 6, endocrine dysfunction doctrine that kinds of doctrine is of the view that the human endocrine system of regulation in animal growth, growth, maturity, aging and death of a family, have an important role, the role is mainly through the endocrine gland secretion of active substance Qi �� hormone. It was suggested that the pituitary to release "aging hormone regularly", the hormone that cells use levothyroxine reduced ability to influence the metabolism of the issue of cell is the cause of the death of aging. Endocrine function reduced pain especially to reduce the level of hormone secretion. 7, somatic mutation theory the theory that, when the biological factors in certain chemical, physical and biological factors, genetic material of biological cells had suddenly changed, causing cell morphology and functional disorder, causing the body's aging process. For example, physicist Silas de proposed: "the radiation can make genetic mutation". He pointed out that, in the high-dose radiation environment in the body of accelerated degeneration, with the aging process is very similar. The basic assumption is that it's a spontaneous mutation of germ cells occur, somatic mutations may occur. Certain somatic mutation causes the function to change, and thus resulting in tissue or organ function decline �� this is the body's aging process. 8, error catastrophe theory this doctrine by miedwie radev. This theory believes in protein synthesis process error most likely occurred, for example, occur the wrong plug phenomenon of amino acids. Protein amino acid that is in strict order (depending on DNA and RNA genetic information), if a synthetic process links error occurs randomly, so that the location of an amino acid is another amino acid in occupies, this is the wrong plug. If the wrong plug parts exactly is protein function most critical region �� enzymes activity center �C serious consequence occurs, the activity will diminish, reduce or even completely specificity of loss of the original functions, with errors have a large number of enzyme synthesis can go wrong, the defective protein, the defective protein accumulation in cells, accumulated to a certain degree of cells is aging andDeath. 9, the doctrine of the theory of aging pigment formed in the beginning of the century. 1892 tears in Hanoi in animal cells found �� kind of Brown autofluorescence of insoluble particles, 1911 boast named lipofuscin. This kind of lipofuscin in animal and human body tissues, and widely distributed along with order gradually increase, so it was called "aging pigment" and that is the cause of aging. Such as the elderly of failure of pigment spots, neurological and cardiac muscle and skeletal muscle cells appear more of lipofuscin, makes the cytoplasmic RNA continued to decline, led to the RNA cannot maintain the metabolism needs, so that cell atrophy or death. 10, the doctrine of the doctrine by crosslinked ferruzzi card in 1924 was first proposed. This doctrine that colloidal exception Crosslinking increased with age, promote cell loss of integrity. Cells and tissues of the existence of a large number of cross-linking reaction occurs, and therefore the ingredients susceptible to a variety of cross-linking reaction. Crosslinking reaction is all in a chemical reaction, the biochemical reactions in the body, as long as a very small amount of cross-linked dry grind, it can cause serious injury to the body. In vivo molecular abnormalities or excessive cross-linking, affecting cells function responsible for aging processes. 11, genetics that aging of genetics that refers to the length of life is from generation to generation. Statistics also show that people have a genetic factors in the horoscope. Scientists speculate that a person's life, there is a designed signal from the germ cells of the parents and the eggs, sperm to offspring. Such a signal called "life gene" or "aging-four", it exists in the cell nucleus in chromosome DNA short. If this gene, cell is not easy to aging. Human cells generally split 50 or so it seems that no longer split in this gene.